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Fast Drug Release Using Rotational Motion of Magnetic Gel Beads
Joint Authors
Takimoto, Jun-Ichi
Mitsumata, Tetsu
Kakiuchi, Yusuke
Source
Research Letters in Physical Chemistry
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Accelerated drug release has been achieved by means of the fast rotation of magnetic gel beads.
The magnetic gel bead consists of sodium alginate crosslinked by calcium chlorides, which contains barium ferrite of ferrimagnetic particles, and ketoprofen as a drug.
The bead underwent rotational motion in response to rotational magnetic fields.
In the case of bead without rotation, the amount of drug release into a phosphate buffer solution obeyed non-Fickian diffusion.
The spontaneous drug release reached a saturation value of 0.90 mg at 25 minutes, which corresponds to 92% of the perfect release.
The drug release was accelerated with increasing the rotation speed.
The shortest time achieving the perfect release was approximately 3 minutes, which corresponds to 1/8 of the case without rotation.
Simultaneous with the fast release, the bead collapsed probably due to the strong water flow surrounding the bead.
The beads with high elasticity were hard to collapse and the fast release was not observed.
Hence, the fast release of ketoprofen is triggered by the collapse of beads.
Photographs of the collapse of beads, time profiles of the drug release, and a pulsatile release modulated by magnetic fields were presented.
American Psychological Association (APA)
Mitsumata, Tetsu& Kakiuchi, Yusuke& Takimoto, Jun-Ichi. 2008. Fast Drug Release Using Rotational Motion of Magnetic Gel Beads. Research Letters in Physical Chemistry،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-489216
Modern Language Association (MLA)
Mitsumata, Tetsu…[et al.]. Fast Drug Release Using Rotational Motion of Magnetic Gel Beads. Research Letters in Physical Chemistry No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-489216
American Medical Association (AMA)
Mitsumata, Tetsu& Kakiuchi, Yusuke& Takimoto, Jun-Ichi. Fast Drug Release Using Rotational Motion of Magnetic Gel Beads. Research Letters in Physical Chemistry. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-489216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489216