The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia
Joint Authors
Maia, Raquel Ciuvalschi
Reis, Flaviana Ruade Souza
Souza, Paloma Silva
Vasconcelos, Flavia Cunha
Nestal de Moraes, Gabriela
Costas, Fernanda Casal de Faria
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Chronic myeloid leukemia (CML) is a clonal hematopoietic disorder characterized by the presence of the Philadelphia chromosome which resulted from the reciprocal translocation between chromosomes 9 and 22.
The pathogenesis of CML involves the constitutive activation of the BCR-ABL tyrosine kinase, which governs malignant disease by activating multiple signal transduction pathways.
The BCR-ABL kinase inhibitor, imatinib, is the front-line treatment for CML, but the emergence of imatinib resistance and other tyrosine kinase inhibitors (TKIs) has called attention for additional resistance mechanisms and has led to the search for alternative drug treatments.
In this paper, we discuss our current understanding of mechanisms, related or unrelated to BCR-ABL, which have been shown to account for chemoresistance and treatment failure.
We focus on the potential role of the influx and efflux transporters, the inhibitor of apoptosis proteins, and transcription factor-mediated signals as feasible molecular targets to overcome the development of TKIs resistance in CML.
American Psychological Association (APA)
Nestal de Moraes, Gabriela& Souza, Paloma Silva& Costas, Fernanda Casal de Faria& Vasconcelos, Flavia Cunha& Reis, Flaviana Ruade Souza& Maia, Raquel Ciuvalschi. 2012. The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-489224
Modern Language Association (MLA)
Nestal de Moraes, Gabriela…[et al.]. The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia. Leukemia Research and Treatment No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-489224
American Medical Association (AMA)
Nestal de Moraes, Gabriela& Souza, Paloma Silva& Costas, Fernanda Casal de Faria& Vasconcelos, Flavia Cunha& Reis, Flaviana Ruade Souza& Maia, Raquel Ciuvalschi. The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-489224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489224