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Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery
Joint Authors
Yasa, Mukadder
Ozsarlak-Sozer, Gonen
Sevin, Gulnur
Akcay, Yasemin Delen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, are the medical treatment of choice for hypercholesterolemia.
In addition to lowering serum-cholesterol levels, statins appear to promote pleiotropic effects that are independent of changes in serum cholesterol.
In this study, we investigated the effects of low-dose fluvastatin on antioxidant enzyme activities (superoxide dismutase, SOD; catalase), total nitrite/nitrate levels, and vascular reactivity in 2% cholesterol-fed rabbits.
This diet did not generate any fatty streak lesions on carotid artery wall.
However, SOD activity significantly increased with cholesterol feeding whereas the catalase activities decreased.
The levels of nitrite/nitrate, stable products of NO degradation, diminished.
Moreover, dietary cholesterol reduced vascular responses to acetylcholine, but contractions to serotonin were augmented.
Fluvastatin treatment abrogated the cholesterol-induced increase in SOD, increased the levels of nitric oxide metabolites in tissue, and restored both the impaired vascular responses to acetylcholine and the augmented contractile responses to serotonin without affecting plasma-cholesterol levels.
Phenylephrine contractions and nitroglycerine vasodilatations did not change in all groups.
This study indicated that fluvastatin treatment performed early enough to improve impaired vascular responses may delay cardiovascular complications associated with several cardiovascular diseases.
American Psychological Association (APA)
Sevin, Gulnur& Akcay, Yasemin Delen& Ozsarlak-Sozer, Gonen& Yasa, Mukadder. 2012. Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489227
Modern Language Association (MLA)
Sevin, Gulnur…[et al.]. Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-489227
American Medical Association (AMA)
Sevin, Gulnur& Akcay, Yasemin Delen& Ozsarlak-Sozer, Gonen& Yasa, Mukadder. Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489227