The Reasons for Discontinuation of Infliximab Treatment in Patients with Crohn's Disease : A Review of Practice at NHS Teaching Hospital
Joint Authors
Kennedy, Hugh J.
Krupa, Lukasz Z.
Hart, Andrew R.
Jamieson, Crawford P.
Fisher, Nicola
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
There is little information on the reasons for discontinuing infliximab treatment in patients with Crohn's disease.
The aim of this study was to document these reasons to determine if any were preventable which would allow patients to continue the therapy.
Aims & Methods.
A review of the medical notes was conducted at the Norfolk and Norwich University Hospital on patients with Crohn's disease treated with infliximab between 2002–2008 to determine the reasons for stopping it.
Results.
A total of 65 patients were identified who had treatment with infliximab, of whom 23 (35.3%) had their therapy stopped.
The reasons for discontinuation of infliximab in the 23 patients were: 47.8% side effects, 17.4% refractory disease, 13.0% achieved remission and did not receive long-term maintenance treatment, 4.34% pregnancy, 4.34% death, and unknown 13.0%.
Conclusions.
The main reasons for the discontinuation of infliximab were side effects rather than a lack of clinical response.
American Psychological Association (APA)
Krupa, Lukasz Z.& Kennedy, Hugh J.& Jamieson, Crawford P.& Fisher, Nicola& Hart, Andrew R.. 2011. The Reasons for Discontinuation of Infliximab Treatment in Patients with Crohn's Disease : A Review of Practice at NHS Teaching Hospital. ISRN Gastroenterology،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-489251
Modern Language Association (MLA)
Krupa, Lukasz Z.…[et al.]. The Reasons for Discontinuation of Infliximab Treatment in Patients with Crohn's Disease : A Review of Practice at NHS Teaching Hospital. ISRN Gastroenterology No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-489251
American Medical Association (AMA)
Krupa, Lukasz Z.& Kennedy, Hugh J.& Jamieson, Crawford P.& Fisher, Nicola& Hart, Andrew R.. The Reasons for Discontinuation of Infliximab Treatment in Patients with Crohn's Disease : A Review of Practice at NHS Teaching Hospital. ISRN Gastroenterology. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-489251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489251