Recanalization Therapies in Acute Ischemic Stroke : Pharmacological Agents, Devices, and Combinations
Joint Authors
Ong, Benjamin K. C.
Su, Jie
Wong, Lily Y. H.
Chan, Bernard P. L.
Teoh, Hock Luen
Sharma, Vijay K.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The primary aim of thrombolysis in acute ischemic stroke is recanalization of an occluded intracranial artery.
Recanalization is an important predictor of stroke outcome as timely restoration of regional cerebral perfusion helps salvage threatened ischemic tissue.
At present, intravenously administered tissue plasminogen activator (IV-TPA) remains the only FDA-approved therapeutic agent for the treatment of ischemic stroke within 3 hours of symptom onset.
Recent studies have demonstrated safety as well as efficacy of IV-TPA even in an extended therapeutic window.
However, the short therapeutic window, low rates of recanalization, and only modest benefits with IV-TPA have prompted a quest for alternative approaches to restore blood flow in an occluded artery in acute ischemic stroke.
Although intra-arterial delivery of the thrombolytic agent seems effective, various logistic constraints limit its routine use and as yet no lytic agent have not received full regulatory approval for intra-arterial therapy.
Mechanical devices and approaches can achieve higher rates of recanalization but their safety and efficacy still need to be established in larger clinical trials.
The field of acute revascularization is rapidly evolving, and various combinations of pharmacologic agents, mechanical devices, and novel microbubble/ultrasound technologies are being tested in multiple clinical trials.
American Psychological Association (APA)
Sharma, Vijay K.& Teoh, Hock Luen& Wong, Lily Y. H.& Su, Jie& Ong, Benjamin K. C.& Chan, Bernard P. L.. 2009. Recanalization Therapies in Acute Ischemic Stroke : Pharmacological Agents, Devices, and Combinations. Stroke Research and Treatment،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-489256
Modern Language Association (MLA)
Sharma, Vijay K.…[et al.]. Recanalization Therapies in Acute Ischemic Stroke : Pharmacological Agents, Devices, and Combinations. Stroke Research and Treatment No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-489256
American Medical Association (AMA)
Sharma, Vijay K.& Teoh, Hock Luen& Wong, Lily Y. H.& Su, Jie& Ong, Benjamin K. C.& Chan, Bernard P. L.. Recanalization Therapies in Acute Ischemic Stroke : Pharmacological Agents, Devices, and Combinations. Stroke Research and Treatment. 2009. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-489256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489256