124Iodine : A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging
Joint Authors
Altini, Corinna
Notaristefano, Antonio
Ferrari, Cristina
Cascini, Giuseppe Lucio
Niccoli Asabella, Artor
Restuccia, Antonino
Rubini, Giuseppe
Rubini, Domenico
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
124Iodine (124I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of 124I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake.
Numerous small molecules and larger compounds like proteins and antibodies have been successfully labeled with 124I.
Advances in radionuclide production allow the effective availability of sufficient quantities of 124I on small biomedical cyclotrons for molecular imaging purposes.
Radioiodination chemistry with 124I relies on well-established radioiodine labeling methods, which consists mainly in nucleophilic and electrophilic substitution reactions.
The physical characteristics of 124I permit taking advantages of the higher PET image quality.
The availability of new molecules that may be targeted with 124I represents one of the more interesting reasons for the attention in nuclear medicine.
We aim to discuss all iodine radioisotopes application focusing on 124I, which seems to be the most promising for its half-life, radiation emissions, and stability, allowing several applications in oncological and nononcological fields.
American Psychological Association (APA)
Cascini, Giuseppe Lucio& Niccoli Asabella, Artor& Notaristefano, Antonio& Restuccia, Antonino& Ferrari, Cristina& Rubini, Domenico…[et al.]. 2014. 124Iodine : A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-489260
Modern Language Association (MLA)
Cascini, Giuseppe Lucio…[et al.]. 124Iodine : A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-489260
American Medical Association (AMA)
Cascini, Giuseppe Lucio& Niccoli Asabella, Artor& Notaristefano, Antonio& Restuccia, Antonino& Ferrari, Cristina& Rubini, Domenico…[et al.]. 124Iodine : A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-489260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489260