DAMPening Inflammation by Modulating TLR Signalling
Joint Authors
Piccinini, A. M.
Midwood, K. S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-13
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Damage-associated molecular patterns (DAMPs) include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue damage.
DAMPs are vital danger signals that alert our immune system to tissue damage upon both infectious and sterile insult.
DAMP activation of Toll-like receptors (TLRs) induces inflammatory gene expression to mediate tissue repair.
However, DAMPs have also been implicated in diseases where excessive inflammation plays a key role in pathogenesis, including rheumatoid arthritis (RA), cancer, and atherosclerosis.
TLR activation by DAMPs may initiate positive feedback loops where increasing tissue damage perpetuates pro-inflammatory responses leading to chronic inflammation.
Here we explore the current knowledge about distinct signalling cascades resulting from self TLR activation.
We also discuss the involvement of endogenous TLR activators in disease and highlight how specifically targeting DAMPs may yield therapies that do not globally suppress the immune system.
American Psychological Association (APA)
Piccinini, A. M.& Midwood, K. S.. 2010. DAMPening Inflammation by Modulating TLR Signalling. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-489283
Modern Language Association (MLA)
Piccinini, A. M.& Midwood, K. S.. DAMPening Inflammation by Modulating TLR Signalling. Mediators of Inflammation No. 2010 (2010), pp.1-21.
https://search.emarefa.net/detail/BIM-489283
American Medical Association (AMA)
Piccinini, A. M.& Midwood, K. S.. DAMPening Inflammation by Modulating TLR Signalling. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-489283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489283