Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem Cell Transplantations for Acute Lymphoblastic Leukemia
Joint Authors
Lang, Peter
Döring, Michaela
Müller, Ingo
Zierl, Angelika
Handgretinger, Rupert
Mezger, Markus
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Systemic fungal infections are a major cause of infection-related mortality in patients with hematologic malignancies.
This report addresses the case of an adolescent patient with acute lymphoblastic leukemia who underwent three allogeneic hematopoietic stem cell transplantations and developed pulmonary aspergillosis.
Combination therapy with liposomal amphotericin B (L-AmB, 3 mg/kg bw/day) and caspofungin (CAS, 50 mg/day) during the first allogeneic hematopoietic stem cell transplantation (HSCT) improved the pulmonary situation.
After shifting the antifungal combination therapy to oral voriconazole (2 × 200 mg/day) and CAS, a new pulmonal lesion occurred alongside the improvements in the existing pulmonary aspergillosis.
An antifungal combination during a second HSCT with L-AmB (3 mg/kg bw/day) and CAS showed an improvement in the pulmonary aspergillosis.
A combination therapy with CAS and L-AmB (1 mg/kg bw/day) during the third HSCT led once again to progress the pulmonary aspergillosis, after increasing the L-AMB to 3 mg/kg bw/day for recovery.
The presented case provides an example of how, despite severe immunosuppression, a combination of antifungal drugs administered intravenously at therapeutic dosages may be more efficient than either intravenous monotherapy or combinations of intravenous and oral antifungals in selecting pediatric and adolescent patients with proven fungal infections.
American Psychological Association (APA)
Döring, Michaela& Zierl, Angelika& Mezger, Markus& Lang, Peter& Handgretinger, Rupert& Müller, Ingo. 2012. Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem Cell Transplantations for Acute Lymphoblastic Leukemia. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-489340
Modern Language Association (MLA)
Döring, Michaela…[et al.]. Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem Cell Transplantations for Acute Lymphoblastic Leukemia. Case Reports in Transplantation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-489340
American Medical Association (AMA)
Döring, Michaela& Zierl, Angelika& Mezger, Markus& Lang, Peter& Handgretinger, Rupert& Müller, Ingo. Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem Cell Transplantations for Acute Lymphoblastic Leukemia. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-489340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489340