Brazilian Propolis Antileishmanial and Immunomodulatory Effects
Joint Authors
Watanabe, Maria Angélica Ehara
da Silva, Suelen Santos
Cataneo, Allan Henrique Depieri
Miranda, Milena Menegazzo
Conchon-Costa, Ivete
Sforcin, José Maurício
Thomé, Graciele da Silva
Piana, Gilce Maria
Felipe, Ionice
Andrade, Célia Guadalupe Tardeli de Jesus
Pavanelli, Wander Rogério
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection.
The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy.
In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L.
(V.) braziliensis.
In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF-α and IL-12 were measured by ELISA.
Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites.
An increased TNF-α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection.
In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell.
The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample.
American Psychological Association (APA)
da Silva, Suelen Santos& Thomé, Graciele da Silva& Cataneo, Allan Henrique Depieri& Miranda, Milena Menegazzo& Felipe, Ionice& Andrade, Célia Guadalupe Tardeli de Jesus…[et al.]. 2013. Brazilian Propolis Antileishmanial and Immunomodulatory Effects. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-489357
Modern Language Association (MLA)
da Silva, Suelen Santos…[et al.]. Brazilian Propolis Antileishmanial and Immunomodulatory Effects. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-489357
American Medical Association (AMA)
da Silva, Suelen Santos& Thomé, Graciele da Silva& Cataneo, Allan Henrique Depieri& Miranda, Milena Menegazzo& Felipe, Ionice& Andrade, Célia Guadalupe Tardeli de Jesus…[et al.]. Brazilian Propolis Antileishmanial and Immunomodulatory Effects. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-489357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489357