Be Careful, Mom and Doc : Hepatotoxicity Associated with Prescribed Medications in Young Infants
Joint Authors
Hon, Kam-Lun Ellis
Leung, Alexander K. C.
Source
International Journal of Pediatrics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-14
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Accidental poisonings in young infants are relatively uncommon, and the careless caregiver is usually the culprit.
We report two cases of hepatotoxicity due to prescribed medications.
An infant was given 15 mL instead of 1.5 mL of paracetamol by his mother because she omitted the decimal point on the label of the drug bottle.
The infant became symptomatic, and liver enzyme and clotting profile were abnormal, necessitating treatment with N-acetyl cysteine.
Another infant was prescribed oral ketoconazole for thrush, resulting in elevation of liver enzymes.
The serum alanine aminotransferase levels were transiently elevated but returned to normal, and both infants recovered uneventfully.
This report serves to alert the doctor to avoid using decimal points in drug labeling and to avoid prescribing excessive amount of drug for trivial acute illness.
Thrush in infancy is common and usually treated with oral nystatin.
Other oral antifungals such as ketoconazole may be associated with liver derangement and should be avoided in infants.
American Psychological Association (APA)
Hon, Kam-Lun Ellis& Leung, Alexander K. C.. 2009. Be Careful, Mom and Doc : Hepatotoxicity Associated with Prescribed Medications in Young Infants. International Journal of Pediatrics،Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-489385
Modern Language Association (MLA)
Hon, Kam-Lun Ellis& Leung, Alexander K. C.. Be Careful, Mom and Doc : Hepatotoxicity Associated with Prescribed Medications in Young Infants. International Journal of Pediatrics No. 2009 (2009), pp.1-3.
https://search.emarefa.net/detail/BIM-489385
American Medical Association (AMA)
Hon, Kam-Lun Ellis& Leung, Alexander K. C.. Be Careful, Mom and Doc : Hepatotoxicity Associated with Prescribed Medications in Young Infants. International Journal of Pediatrics. 2009. Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-489385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489385