Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase : Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have reported previously that daily intravenous infusions of a soluble nanobiotechnological complex, polyhemoglobin-tyrosinase [polyHb-Tyr], can suppress the growth of murine B16F10 melanoma in a mouse model.
In order to avoid the need for daily intravenous injections, we have now extended this further as follows.
We have prepared two types of biodegradable nanocapsules containing [polyHb-Tyr].
One type is to increase the circulation time and decrease the frequency of injection and is based on polyethyleneglycol-polylactic acid (PEG-PLA) nanocapsules containing [polyHb-Tyr].
The other type is to allow for intratumoural or local injection and is based on polylactic acid (PLA) nanocapsules containing [polyHb-Tyr].
Cell culture studies show that it can inhibit the proliferation of murine B16F10 melanoma cells in the “proliferation model”.
It can also inhibit the attachment of murine B16F10 melanoma cells in the “attachment model.” This could be due to the action of tyrosinase on the depletion of tyrosine or the toxic effect of tyrosine metabolites.
The other component, polyhemoglobin (polyHb), plays a smaller role in nanocapsules containing [polyHb-Tyr], and this is most likely by its depletion of nitric oxide needed for melanoma cell growth.
American Psychological Association (APA)
Wang, Yun& Chang, Thomas M. S.. 2012. Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase : Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment. Journal of Skin Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489389
Modern Language Association (MLA)
Wang, Yun& Chang, Thomas M. S.. Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase : Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment. Journal of Skin Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-489389
American Medical Association (AMA)
Wang, Yun& Chang, Thomas M. S.. Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase : Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment. Journal of Skin Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489389