Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease : A Study in a Dry-Land Maze
Joint Authors
Neumeister, Katharina L.
Riepe, Matthias W.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Incipient Alzheimer's disease is often disguised as depressive disorder.
Over the course of AD, depressive symptoms are even more frequent.
Hence, treatment with antidepressants is common in AD.
It was the goal of the present study to assess whether two common antidepressants with different mechanisms of action affect spatial learning in a transgenic animal model of Alzheimer's disease.
Methods.
We assessed spatial memory of male wild-type and B6C3-Tg(APPswe,PSEN1dE9)85Dbo (APP23) transgenic animals in a complex dry-land maze.
Animals were treated with citalopram (10 mg/kg) and bupropion (20 mg/kg).
Results.
Moving and resting time until finding the goal zone decreased in 4.5-month-old sham-treated wild-type animals and, to a lesser extent, in APP23 animals.
Compared with sham-treated APP23 animals, treatment with bupropion reduced resting time and increased speed.
On treatment with citalopram, moving and resting time were unchanged but speed decreased.
Length of the path to the goal zone did not change on either bupropion or citalopram.
Conclusion.
Bupropion increases psychomotor activity in APP23 transgenic animals, while citalopram slightly reduces psychomotor activity.
Spatial learning per se is unaffected by treatment with either bupropion or citalopram.
American Psychological Association (APA)
Neumeister, Katharina L.& Riepe, Matthias W.. 2012. Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease : A Study in a Dry-Land Maze. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489409
Modern Language Association (MLA)
Neumeister, Katharina L.& Riepe, Matthias W.. Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease : A Study in a Dry-Land Maze. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-489409
American Medical Association (AMA)
Neumeister, Katharina L.& Riepe, Matthias W.. Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease : A Study in a Dry-Land Maze. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489409