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Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity : Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients
Joint Authors
Brown, Paula
Mahajan, Supriya D.
Sykes, Donald E.
Reynolds, Jessica L.
Schwartz, Stanley A.
Aalinkeel, Ravikumar
Wheeler, John C.
Nair, Bindukumar
Source
International Journal of Proteomics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Proteomic profiles of RAST+ subjects with severe food allergies and RAST− subjects were compared using 2D-DIGE analysis to obtain candidate biomarkers specific to food allergies.
Our analysis highlighted 52 proteins that were differentially expressed between the RAST+ and RAST− groups of which 37 were successfully identified that include chondroitin sulfates, zinc finger proteins, C-type lectins, retinoic acid binding proteins, heat shock proteins, myosin, cytokines, mast cell expressed proteins, and MAP kinases.
Biological network analysis tool Metacore revealed that most of these regulated proteins play a role in immune tolerance, hypersensitivity and modulate cytokine patterns inducing a Th2 response that typically results in IgE-mediated allergic response which has a direct or indirect biological link to food allergy.
Identifying unique biomarkers associated with certain allergic phenotypes and potentially cross-reactive proteins through bioinformatics analyses will provide enormous insight into the mechanisms that underlie allergic response in patients with food allergies.
American Psychological Association (APA)
Nair, Bindukumar& Wheeler, John C.& Sykes, Donald E.& Brown, Paula& Reynolds, Jessica L.& Aalinkeel, Ravikumar…[et al.]. 2011. Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity : Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-489415
Modern Language Association (MLA)
Nair, Bindukumar…[et al.]. Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity : Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients. International Journal of Proteomics No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-489415
American Medical Association (AMA)
Nair, Bindukumar& Wheeler, John C.& Sykes, Donald E.& Brown, Paula& Reynolds, Jessica L.& Aalinkeel, Ravikumar…[et al.]. Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity : Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-489415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489415