Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma
Joint Authors
Schoenberger, Scott D.
Kim, Stephen J.
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Newer chemotherapeutic agents target extracellular signaling, including the mitogen-activated protein kinase kinase (MEK) pathway.
We present a case of a 54-year-old female who developed bilateral multifocal central serous-like chorioretinopathy shortly after starting MEK inhibition for metastatic cutaneous melanoma.
There was a complete resolution of findings after drug stoppage.
After resuming a lower dose of the MEK inhibitor, the findings recurred again but resolved after drug stoppage.
Other etiologies were unlikely given the clinical course.
The presumed mechanism involves toxicity to the retinal pigment epithelium, with breakdown of the blood-retinal barrier.
Recognition of this side effect is important with this new class of chemotherapy.
American Psychological Association (APA)
Schoenberger, Scott D.& Kim, Stephen J.. 2013. Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma. Case Reports in Ophthalmological Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-489432
Modern Language Association (MLA)
Schoenberger, Scott D.& Kim, Stephen J.. Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma. Case Reports in Ophthalmological Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-489432
American Medical Association (AMA)
Schoenberger, Scott D.& Kim, Stephen J.. Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma. Case Reports in Ophthalmological Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-489432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489432