Anti-Müllerian Hormone : A Valuable Addition to the Toolbox of the Pediatric Endocrinologist
Joint Authors
Picard, Jean-Yves
Josso, Nathalie
Rey, Rodolfo A.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anti-Müllerian hormone (AMH), secreted by immature Sertoli cells, provokes the regression of male fetal Müllerian ducts.
FSH stimulates AMH production; during puberty, AMH is downregulated by intratesticular testosterone and meiotic germ cells.
In boys, AMH determination is useful in the clinical setting.
Serum AMH, which is low in infants with congenital central hypogonadism, increases with FSH treatment.
AMH is also low in patients with primary hypogonadism, for instance in Down syndrome, from early postnatal life and in Klinefelter syndrome from midpuberty.
In boys with nonpalpable gonads, AMH determination, without the need for a stimulation test, is useful to distinguish between bilaterally abdominal gonads and anorchism.
In patients with disorders of sex development (DSD), serum AMH determination helps as a first line test to orientate the etiologic diagnosis: low AMH is indicative of dysgenetic DSD whereas normal AMH is suggestive of androgen synthesis or action defects.
Finally, in patients with persistent Müllerian duct syndrome (PMDS), undetectable serum AMH drives the genetic search to mutations in the AMH gene, whereas normal or high AMH is indicative of an end organ defect due to AMH receptor gene defects.
American Psychological Association (APA)
Josso, Nathalie& Rey, Rodolfo A.& Picard, Jean-Yves. 2013. Anti-Müllerian Hormone : A Valuable Addition to the Toolbox of the Pediatric Endocrinologist. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-489460
Modern Language Association (MLA)
Josso, Nathalie…[et al.]. Anti-Müllerian Hormone : A Valuable Addition to the Toolbox of the Pediatric Endocrinologist. International Journal of Endocrinology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-489460
American Medical Association (AMA)
Josso, Nathalie& Rey, Rodolfo A.& Picard, Jean-Yves. Anti-Müllerian Hormone : A Valuable Addition to the Toolbox of the Pediatric Endocrinologist. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-489460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489460