Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects
Joint Authors
Olszanecka-Glinianowicz, Magdalena
Juszczyk, Łukasz
Żak-Gołąb, Agnieszka
Chudek, Jerzy
Aptekorz, Małgorzata
Martirosian, Gayane
Zientara, Maria
Kocełak, Piotr
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The association between gut microbiota and circulating zonulin level, a marker of intestinal permeability, has not been studied yet.
The aim of the study is the assessment of plasma zonulin, haptoglobin and proinflammatory cytokines (TNF-α and IL-6) levels in relation to composition of gut microbiota in obese and normal weight subjects.
Circulating inflammation markers, such as TNF-α, sTNFR1, sTNFR2, IL-6, zonulin, and haptoglobin levels were measured and semiquantitative analysis of gut microbiota composition was carried out in 50 obese and 30 normal weight subjects without concomitant diseases.
Higher circulating zonulin, TNF-α, sTNFR1, sTNFR2, and IL-6 levels were found in the obese subjects.
Plasma zonulin level correlated positively with age (r=0.43, P<0.001), body mass (r=0.30, P<0.01), BMI (r=0.33, P<0.01), fat mass and fat percentage (r=0.31, P<0.01 and r=0.23, P<0.05, resp.).
Positive correlations between bacterial colony count and sTNFR1 (r=0.33, P<0.01) and plasma zonulin (r=0.26, P<0.05) but not haptoglobin levels were found.
Additionally, plasma zonulin level was proportional to daily energy intake (r=0.27, P<0.05) and serum glucose concentration (r=0.18, P<0.05) and inversely proportional to diet protein percentage (r=-0.23, P<0.05).
Gut microbiota-related systemic microinflammation in the obese is reflected by circulating zonulin level, a potential marker of interstitial permeability.
American Psychological Association (APA)
Żak-Gołąb, Agnieszka& Kocełak, Piotr& Aptekorz, Małgorzata& Zientara, Maria& Juszczyk, Łukasz& Martirosian, Gayane…[et al.]. 2013. Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489461
Modern Language Association (MLA)
Żak-Gołąb, Agnieszka…[et al.]. Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects. International Journal of Endocrinology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489461
American Medical Association (AMA)
Żak-Gołąb, Agnieszka& Kocełak, Piotr& Aptekorz, Małgorzata& Zientara, Maria& Juszczyk, Łukasz& Martirosian, Gayane…[et al.]. Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489461