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Targeting TLRIL-1R Signalling in Human Diseases
Joint Authors
Loiarro, Maria
Sette, Claudio
Ruggiero, Vito
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The members of Toll-like receptor/Interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response.
These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes.
On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of their function.
In this review, we illustrate the structural and functional features of TLR/IL-1R proteins and discuss some recent advances in the approaches undertaken to develop anti-inflammatory therapeutic drugs.
In particular, we will focus on inhibitors, such as decoy peptides and synthetic mimetics, that interfere with protein-protein interactions between signalling molecules of the TLR/IL-1R superfamily.
Given their central role in innate and adaptive immune responses, it is foreseen that pharmaceutical modulation of TLR/IL-1R signalling pathways by these drugs might yield clinical benefits in the treatment of inflammatory and autoimmune diseases.
American Psychological Association (APA)
Loiarro, Maria& Ruggiero, Vito& Sette, Claudio. 2010. Targeting TLRIL-1R Signalling in Human Diseases. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-489502
Modern Language Association (MLA)
Loiarro, Maria…[et al.]. Targeting TLRIL-1R Signalling in Human Diseases. Mediators of Inflammation No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-489502
American Medical Association (AMA)
Loiarro, Maria& Ruggiero, Vito& Sette, Claudio. Targeting TLRIL-1R Signalling in Human Diseases. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-489502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489502