Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form
Joint Authors
Bhatt, Kashyap K.
Baldania, Sunil L.
Chhalotiya, Usmangani K.
Suthar, Dixita J.
Shah, Dimal A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
An isocratic, reversed phase-liquid-chromatographic assay method was developed for the quantitative determination of ibuprofen and famotidine in combined-dosage form.
A Brownlee C18, 5 μm column with mobile phase containing water : methanol : acetonitrile (30 : 60 : 10, v/v/v) was used.
The flow rate was 1.0 mL/min, and effluents were monitored at 264 nm.
The retention times of ibuprofen and famotidine were 4.9 min and 6.8 min, respectively.
The linearity for ibuprofen and famotidine was in the range of 2–20 μg/mL and 0.1–10 μg/mL, respectively.
The proposed method was validated with respect to linearity, accuracy, precision, specificity, and robustness.
The method was successfully applied to the estimation of ibuprofen and famotidine in combined dosage form.
American Psychological Association (APA)
Shah, Dimal A.& Suthar, Dixita J.& Baldania, Sunil L.& Chhalotiya, Usmangani K.& Bhatt, Kashyap K.. 2012. Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-489507
Modern Language Association (MLA)
Shah, Dimal A.…[et al.]. Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form. ISRN Analytical Chemistry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-489507
American Medical Association (AMA)
Shah, Dimal A.& Suthar, Dixita J.& Baldania, Sunil L.& Chhalotiya, Usmangani K.& Bhatt, Kashyap K.. Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-489507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489507