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Pathogenesis of Chronic Urticaria : An Overview
Author
Source
Dermatology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The pathogenesis of chronic urticaria is not well delineated and the treatment is palliative as it is not tied to the pathomechanism.
The centrality of mast cells and their inappropriate activation and degranulation as the key pathophysiological event are well established.
The triggering stimuli and the complexity of effector mechanisms remain speculative.
Autoimmune origin of chronic urticaria, albeit controversial, is well documented.
Numerical and behavioral alterations in basophils accompanied by changes in signaling molecule expression and function as well as aberrant activation of extrinsic pathway of coagulation are other alternative hypotheses.
It is also probable that mast cells are involved in the pathogenesis through mechanisms that extend beyond high affinity IgE receptor stimulation.
An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation.
It is likely that these different pathomechanisms are interlinked rather than independent cascades, acting either synergistically or sequentially to produce clinical expression of chronic urticaria.
Insights into the complexities of pathogenesis may provide an impetus to develop safer, efficacious, and targeted immunomodulators and biological treatment for severe, refractory chronic urticaria.
American Psychological Association (APA)
Jain, Sanjiv. 2014. Pathogenesis of Chronic Urticaria : An Overview. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489522
Modern Language Association (MLA)
Jain, Sanjiv. Pathogenesis of Chronic Urticaria : An Overview. Dermatology Research and Practice No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-489522
American Medical Association (AMA)
Jain, Sanjiv. Pathogenesis of Chronic Urticaria : An Overview. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489522