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Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease
Joint Authors
Maruyama, Hirofumi
Ma, Jianjun
Kamada, Masaki
Zhang, Yanmin
Xu, Changshui
Xu, Jun
Kawakami, Hideshi
Source
Neurology Research International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD).
Methods.
Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-induced putative kinase 1), PARK7(Protein DJ1), PARK2(Parkinson juvenile disease protein 2), the glucocerebrosidase (GBA), and ATP(Ezrin-binding protein PACE-1), were sequenced by the use of polymerase chain reaction (PCR) technique.
The gene dose of SNCA was checked.
Results.
There were only two missense mutations observed, respectively, at exon 5 of LRRK2 and exon 10 of PARK2, and both were enrolled in SNPs.
Conclusion.
No meaningful mutations could be detected, and other susceptibility genes should be detected in FDP patients in China.
American Psychological Association (APA)
Xu, Changshui& Xu, Jun& Zhang, Yanmin& Ma, Jianjun& Kawakami, Hideshi& Maruyama, Hirofumi…[et al.]. 2010. Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease. Neurology Research International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-489525
Modern Language Association (MLA)
Xu, Changshui…[et al.]. Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease. Neurology Research International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-489525
American Medical Association (AMA)
Xu, Changshui& Xu, Jun& Zhang, Yanmin& Ma, Jianjun& Kawakami, Hideshi& Maruyama, Hirofumi…[et al.]. Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease. Neurology Research International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-489525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489525