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Clear Cell Carcinomas of the Mullerian System : Does the Pathogenesis Vary Depending on Their Nuclear Grade and Their Association with Endometriosis? An Immunohistochemical Analysis
Joint Authors
Alduaij, Ahmad
Sung, C. James
Karim, Tahreem A.
Lomme, Michelle M.
Lawrence, W. Dwayne
Zhang, Cunxian
Quddus, M. Ruhul
Hansen, Katrine
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Clear cell carcinomas (CCC) of the mullerian system are considered high grade tumors, but morphologically, the cells of CCC show both low and high grade features.
The aims of the current study were to categorize CCC into low and high nuclear grade types, correlate their association with endometriosis, and then observe possible variations in pathogenesis based on their expression of p53 and Ki-67.
We studied 41 pure mullerian CCCs and designated each as either a high (HNG) or low (LNG) nuclear grade tumor.
Morphologically, 17 (41%) CCCs were LNG and 24 (59%) were HNG.
Nine (38%) HNG and 2 (12%) LNG tumors showed positive immunostaining with p53.
Endometriosis was associated with 8 (47%) LNG tumors and 8 (33%) HNG CCCs.
Of the 11 cases with p53 alteration, 4 (1 LNG and 3 HNG) were associated with endometriosis.
Conclusions: HNG CCCs, irrespective of their association with endometriosis, have alterations of p53.
In general, LNG ovarian and endometrial CCCs, irrespective of their association with endometriosis/adenomyosis, are less likely to show p53 alteration.
It appears that mullerian CCCs may have variable pathogenesis depending on their nuclear grade and association with endometriosis.
A larger study is needed to validate these findings.
American Psychological Association (APA)
Alduaij, Ahmad& Hansen, Katrine& Karim, Tahreem A.& Zhang, Cunxian& Lomme, Michelle M.& Sung, C. James…[et al.]. 2012. Clear Cell Carcinomas of the Mullerian System : Does the Pathogenesis Vary Depending on Their Nuclear Grade and Their Association with Endometriosis? An Immunohistochemical Analysis. Pathology Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-489526
Modern Language Association (MLA)
Alduaij, Ahmad…[et al.]. Clear Cell Carcinomas of the Mullerian System : Does the Pathogenesis Vary Depending on Their Nuclear Grade and Their Association with Endometriosis? An Immunohistochemical Analysis. Pathology Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-489526
American Medical Association (AMA)
Alduaij, Ahmad& Hansen, Katrine& Karim, Tahreem A.& Zhang, Cunxian& Lomme, Michelle M.& Sung, C. James…[et al.]. Clear Cell Carcinomas of the Mullerian System : Does the Pathogenesis Vary Depending on Their Nuclear Grade and Their Association with Endometriosis? An Immunohistochemical Analysis. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-489526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489526