The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors
Joint Authors
Perumalsamy, Lakshmi R.
Garg, Megha
Sarin, Apurva
Shivashankar, G. V.
Source
International Journal of Cell Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tissue homeostasis is a dynamic process involving proliferation and the removal of redundant or damaged cells.
This is exemplified in the coordinated deletion—triggered by limiting trophic factors/cytokines in the extracellular milieu—of differentiated T cells overproduced during the mammalian immune response.
However, mechanisms by which extracellular cues are perceived and transduced as apoptotic triggers remain incompletely understood.
T-effectors are dependent on cytokines for survival and undergo apoptosis following cytokine withdrawal.
Here we report that leptomycin B (LMB), an inhibitor of nuclear export machinery, protected T-effectors from apoptosis implicating a nuclear intermediate in the apoptotic pathway.
Evidence is presented that the linker histone H1.2 localizes to the cytoplasm, by a mechanism sensitive to regulation by LMB, to activate apoptotic signaling culminating in nuclear and mitochondrial damage in T-effectors in response to cytokine deprivation.
H1.2 is detected in a complex with the proapoptotic mitochondrial resident Bak and its subcellular localization regulated by Jun-N-terminal kinase (JNK), an intermediate in the apoptotic cascade in T-effectors.
These data suggest that metabolic stressors may impinge on H1.2 dynamics favoring its activity at the mitochondrion, thereby functioning as a molecular switch for T-effector apoptosis.
American Psychological Association (APA)
Garg, Megha& Perumalsamy, Lakshmi R.& Shivashankar, G. V.& Sarin, Apurva. 2014. The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-489528
Modern Language Association (MLA)
Garg, Megha…[et al.]. The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors. International Journal of Cell Biology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-489528
American Medical Association (AMA)
Garg, Megha& Perumalsamy, Lakshmi R.& Shivashankar, G. V.& Sarin, Apurva. The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-489528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489528