Ceramide in Cystic Fibrosis : A Potential New Target for Therapeutic Intervention
Joint Authors
De Sanctis, Juan B.
Radzioch, Danuta
Wojewodka, Gabriella
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Patients with cystic fibrosis (CF) are afflicted with many symptoms but the greatest challenge is the fight against chronic bacterial infections, leading to decreased lung function and ultimately death.
Our group has recently found reduced levels of ceramides in CF patients and mice.
Ceramides are sphingolipids involved in the structure of cell membranes but also participate in the inflammatory response, in cell signalling through membrane microdomains (lipid rafts), and in apoptosis.
These characteristics of ceramides make them strong candidates for therapeutic intervention in CF.
As more studies have come to evaluate the role of ceramide in CF, conflicting results have been described.
This paper discusses various views regarding the potential role of ceramide in CF, summarizes methods of ceramide detection and their role in the regulation of cellular and molecular processes.
American Psychological Association (APA)
Wojewodka, Gabriella& De Sanctis, Juan B.& Radzioch, Danuta. 2010. Ceramide in Cystic Fibrosis : A Potential New Target for Therapeutic Intervention. Journal of Lipids،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-489550
Modern Language Association (MLA)
Wojewodka, Gabriella…[et al.]. Ceramide in Cystic Fibrosis : A Potential New Target for Therapeutic Intervention. Journal of Lipids No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-489550
American Medical Association (AMA)
Wojewodka, Gabriella& De Sanctis, Juan B.& Radzioch, Danuta. Ceramide in Cystic Fibrosis : A Potential New Target for Therapeutic Intervention. Journal of Lipids. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-489550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489550