Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction
Joint Authors
Miura, Yasuo
Kaneko, Hitomi
Tsudo, Mitsuru
Matsui, Yusuke
Watanabe, Mitsumasa
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Iron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions.
Recently, deferasirox (DSX), a novel, once-daily oral iron chelator, was demonstrated to have similar efficacy to the conventional continuous infusion of deferoxamine on a decrease in serum ferritin (SF) level in heavily transfused patients.
We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT).
All three patients who received the ICT with DSX showed a decrease in ALT level in association with a decrease in SF level.
It is suggested that DSX therapy could be considered to expect the improvement of liver damage for iron-overloaded patients with an abnormal ALT level.
American Psychological Association (APA)
Miura, Yasuo& Matsui, Yusuke& Kaneko, Hitomi& Watanabe, Mitsumasa& Tsudo, Mitsuru. 2010. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction. Case Reports in Medicine،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-489557
Modern Language Association (MLA)
Miura, Yasuo…[et al.]. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction. Case Reports in Medicine No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-489557
American Medical Association (AMA)
Miura, Yasuo& Matsui, Yusuke& Kaneko, Hitomi& Watanabe, Mitsumasa& Tsudo, Mitsuru. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction. Case Reports in Medicine. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-489557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489557