The Role of T-Cell Leukemia Translocation-Associated Gene Protein in Human Tumorigenesis and Osteoclastogenesis
Joint Authors
Nanke, Yuki
Kotake, Shigeru
Yago, Toru
Kawamoto, Manabu
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Synovial tissues of patients with rheumatoid arthritis (RA) include factors regulating bone resorption, such as receptor activator NF-κB ligand (RANKL), TNF-α, IL-6, IL-17, and IFN-γ.
However, in addition to these cytokines, other factors expressed in synovial tissues may play a role in regulating bone resorption.
In 2009, we demonstrated that novel peptides from T-cell leukemia translocation-associated gene (TCTA) protein expressed in synovial tissues from patients with RA inhibit human osteoclastogenesis, preventing cellular fusion via the interaction between TCTA protein and a putative counterpart molecule.
Only a few studies on the role of TCTA protein have been reported.
Genomic Southern blots demonstrated a reduced TCTA signal in three of four small cell lung cancer cell lines, suggesting the loss of one of the two copies of the gene.
In the current paper, we reviewed the roles of TCTA protein in lung cancer cell lines and human osteoclastogenesis.
American Psychological Association (APA)
Kotake, Shigeru& Yago, Toru& Kawamoto, Manabu& Nanke, Yuki. 2011. The Role of T-Cell Leukemia Translocation-Associated Gene Protein in Human Tumorigenesis and Osteoclastogenesis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489579
Modern Language Association (MLA)
Kotake, Shigeru…[et al.]. The Role of T-Cell Leukemia Translocation-Associated Gene Protein in Human Tumorigenesis and Osteoclastogenesis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-489579
American Medical Association (AMA)
Kotake, Shigeru& Yago, Toru& Kawamoto, Manabu& Nanke, Yuki. The Role of T-Cell Leukemia Translocation-Associated Gene Protein in Human Tumorigenesis and Osteoclastogenesis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489579