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Inflammatory Markers in Middle-Aged Obese Subjects : Does Obstructive Sleep Apnea Syndrome Play a Role?
Joint Authors
Antoniadou, Maria
Papanas, Nikolaos
Bouros, Demosthenes
Tzouvelekis, Argyris
Tsara, Venetia
Kyriazis, Georgios
Hatzizisi, Olga
Serasli, Evangelia
Nena, Evangelia
Papoti, Sophia
Steiropoulos, Paschalis
Maltezos, Efstratios
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Obstructive Sleep Apnea Syndrome (OSAS) is associated with inflammation, but obesity may be a confounding factor.
Thus, the aim of this study was to explore differences in serum levels of inflammation markers between obese individuals with or without OSAS.
Methods.
Healthy individuals (n=61) from an outpatient obesity clinic were examined by polysomnography and blood analysis, for measurement of TNF-α, IL-6, CRP, and fibrinogen levels.
According to Apnea-Hypopnea Index (AHI), participants were divided into two BMI-matched groups: controls (AHI < 15/h, n=23) and OSAS patients (AHI ≥ 15/h, n=38).
Results.
OSAS patients had significantly higher TNF-α levels (P<.001) while no other difference in the examined inflammation markers was recorded between groups.
Overall, TNF-α levels were correlated with neck circumference (P<.001), AHI (P=.002), and Oxygen Desaturation Index (P=.002).
Conclusions.
Obese OSAS patients have elevated TNF-α levels compared to BMI-matched controls, suggesting a role of OSAS in promoting inflammation, possibly mediated by TNF-a.
American Psychological Association (APA)
Steiropoulos, Paschalis& Papanas, Nikolaos& Nena, Evangelia& Antoniadou, Maria& Serasli, Evangelia& Papoti, Sophia…[et al.]. 2010. Inflammatory Markers in Middle-Aged Obese Subjects : Does Obstructive Sleep Apnea Syndrome Play a Role?. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-489580
Modern Language Association (MLA)
Steiropoulos, Paschalis…[et al.]. Inflammatory Markers in Middle-Aged Obese Subjects : Does Obstructive Sleep Apnea Syndrome Play a Role?. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-489580
American Medical Association (AMA)
Steiropoulos, Paschalis& Papanas, Nikolaos& Nena, Evangelia& Antoniadou, Maria& Serasli, Evangelia& Papoti, Sophia…[et al.]. Inflammatory Markers in Middle-Aged Obese Subjects : Does Obstructive Sleep Apnea Syndrome Play a Role?. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-489580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489580