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Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina
Joint Authors
Maiti, Anup
Sahu, Ranabir
Dua, Tarun K.
Dewanjee, Saikat
Mandal, Vivekananda
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The matured fruits of Diospyros peregrina are successfully employed by the traditional healers and local people of costal West Bengal, India for the treatment of diabetes.
Present investigation was undertaken to evaluate the role of hydroalcoholic extract of D.
peregrina (HDP) on type 2 diabetes as well as the augmented oxidative stresses associated with it.
Oral administration of HDP at 25, 50 and 100 mg kg−1 body weight per day to diabetic rats was found to possess significant dose-dependent hypoglycemic and hypolipidemic activity.
The diabetic rats showed lower activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) content in hepatic and renal tissues as compared to normal rats.
The activities of SOD, CAT and GSH were found to be increased in extract-treated diabetic rats in selected tissues.
The increased level of lipid peroxidation (thiobarbituric acid reactive substances) in diabetic rats was also found to be reverted back to near normal status in extract-treated groups.
Thus it may be concluded that the HDP may produce its hypoglycemic effect through antioxidant defense mechanism.
American Psychological Association (APA)
Dewanjee, Saikat& Maiti, Anup& Sahu, Ranabir& Dua, Tarun K.& Mandal, Vivekananda. 2011. Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-489591
Modern Language Association (MLA)
Dewanjee, Saikat…[et al.]. Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-489591
American Medical Association (AMA)
Dewanjee, Saikat& Maiti, Anup& Sahu, Ranabir& Dua, Tarun K.& Mandal, Vivekananda. Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-489591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489591