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State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake
Joint Authors
De Sá Júnior, Paulo Luiz
Rádis-Baptista, Gandhi
Kerkis, Alexandre
Yamane, Tetsuo
Prieto da Silva, Alvaro R. B.
Kerkis, Irina
Zaharenko, Andre J.
Hayashi, Mirian A. F.
Pereira, Alexandre
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Animal venoms comprise a naturally selected cocktail of bioactive peptides/proteins and other molecules, each of which playing a defined role thanks to the highly specific interactions with diverse molecular targets found in the prey.
Research focused on isolation, structural, and functional characterizations of novel natural biologics (bioactive peptides/proteins from natural sources) has a long way to go through from the basic science to clinical applications.
Herein, we overview the structural and functional characteristics of the myoneurotoxin crotamine, firstly isolated from the South American rattlesnake venom.
Crotamine is the first venom peptide classified as a natural cell penetrating and antimicrobial peptide (CPP and AMP) with a more pronounced antifungal activity.
In contrast to other known natural CPPs and AMPs, crotamine demonstrates a wide spectrum of biological activities with potential biotechnological and therapeutic values.
More recent studies have demonstrated the selective in vitro anticancer activity of crotamine.
In vivo, using a murine melanoma model, it was shown that crotamine delays tumor implantation, inhibits tumor cells proliferation, and also increases the survival of mice engrafted with subcutaneous melanoma.
The structural and functional properties and also the possible biotechnological applications of minimized molecules derived from crotamine are also discussed.
American Psychological Association (APA)
Kerkis, Irina& Hayashi, Mirian A. F.& Prieto da Silva, Alvaro R. B.& Pereira, Alexandre& De Sá Júnior, Paulo Luiz& Zaharenko, Andre J.…[et al.]. 2014. State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489631
Modern Language Association (MLA)
Kerkis, Irina…[et al.]. State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-489631
American Medical Association (AMA)
Kerkis, Irina& Hayashi, Mirian A. F.& Prieto da Silva, Alvaro R. B.& Pereira, Alexandre& De Sá Júnior, Paulo Luiz& Zaharenko, Andre J.…[et al.]. State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489631