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Understanding Immunology via Engineering Design : The Role of Mathematical Prototyping
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A major challenge in immunology is how to translate data into knowledge given the inherent complexity and dynamics of human physiology.
Both the physiology and engineering communities have rich histories in applying computational approaches to translate data obtained from complex systems into knowledge of system behavior.
However, there are some differences in how disciplines approach problems.
By referring to mathematical models as mathematical prototypes, we aim to highlight aspects related to the process (i.e., prototyping) rather than the product (i.e., the model).
The objective of this paper is to review how two related engineering concepts, specifically prototyping and “fitness for use,” can be applied to overcome the pressing challenge in translating data into improved knowledge of basic immunology that can be used to improve therapies for disease.
These concepts are illustrated using two immunology-related examples.
The prototypes presented focus on the beta cell mass at the onset of type 1 diabetes and the dynamics of dendritic cells in the lung.
This paper is intended to illustrate some of the nuances associated with applying mathematical modeling to improve understanding of the dynamics of disease progression in humans.
American Psychological Association (APA)
Klinke, David J.& Wang, Qing. 2012. Understanding Immunology via Engineering Design : The Role of Mathematical Prototyping. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489633
Modern Language Association (MLA)
Klinke, David J.& Wang, Qing. Understanding Immunology via Engineering Design : The Role of Mathematical Prototyping. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-489633
American Medical Association (AMA)
Klinke, David J.& Wang, Qing. Understanding Immunology via Engineering Design : The Role of Mathematical Prototyping. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489633