Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form
Joint Authors
Jadhav, Monika L.
Tambe, Santosh R.
Source
Chromatography Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chromatographic and spectrophotometric methods were developed according to Quality by Design (QbD) approach as per ICH Q8(R2) guidelines for estimation of propafenone hydrochloride in tablet dosage form.
QbD approach was carried out by varying various parameters and these variable parameters were designed into Ishikawa diagram.
The critical parameters were determined by using principal component analysis as well as by observation.
Estimated critical parameters in HPTLC method include solvent methanol, mode of detection absorbance, precoated aluminium backed TLC plate (10 cm × 10 cm), wavelength: 250 nm, saturation time: 20 min, band length: 8 mm, solvent front: 70 mm, volume of mobile phase: 5 mL, type of chamber: 10 cm × 10 cm, scanning time: 10 min, and mobile phase methanol : ethyl acetate : triethylamine (1.5 : 3.5 : 0.4 v/v/v).
Estimated critical parameters in zero order spectrophotometric method were solvent methanol, sample preparation tablet, wavelength: 247.4 nm, slit width: 1.0, scan speed medium, and sampling interval: 0.2, and for first order derivative spectrophotometric method it was scaling factor: 5 and delta lambda 4.
The above methods were validated according to ICH Q2(R1) guidelines.
Proposed methods can be used for routine analysis of propafenone hydrochloride in tablet dosage form as they were found to be robust and specific.
American Psychological Association (APA)
Jadhav, Monika L.& Tambe, Santosh R.. 2013. Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form. Chromatography Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489683
Modern Language Association (MLA)
Jadhav, Monika L.& Tambe, Santosh R.. Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form. Chromatography Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489683
American Medical Association (AMA)
Jadhav, Monika L.& Tambe, Santosh R.. Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form. Chromatography Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489683