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Cancer Cell Adhesion and Metastasis : Selectins, Integrins, and the Inhibitory Potential of Heparins
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cell adhesion molecules play a significant role in cancer progression and metastasis.
Cell-cell interactions of cancer cells with endothelium determine the metastatic spread.
In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions.
Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival.
Preclinical studies confirm that heparin possesses antimetastatic activities that lead to attenuation of metastasis in various animal models.
Heparin contains several biological activities that may affect several steps in metastatic cascade.
Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion.
While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression.
This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and antimetastatic activities of heparin.
American Psychological Association (APA)
Bendas, Gerd& Borsig, Lubor. 2012. Cancer Cell Adhesion and Metastasis : Selectins, Integrins, and the Inhibitory Potential of Heparins. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-489693
Modern Language Association (MLA)
Bendas, Gerd& Borsig, Lubor. Cancer Cell Adhesion and Metastasis : Selectins, Integrins, and the Inhibitory Potential of Heparins. International Journal of Cell Biology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-489693
American Medical Association (AMA)
Bendas, Gerd& Borsig, Lubor. Cancer Cell Adhesion and Metastasis : Selectins, Integrins, and the Inhibitory Potential of Heparins. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-489693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489693