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DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
Joint Authors
Santos, Janine Hertzog
Rudge, Marilza Vieira Cunha
Calderon, Iracema de Mattos Paranhos
Morceli, Glilciane
Bevilacqua, Estela
Rocha, Clarissa Ribeiro
Damasceno, Débora Cristina
Moreli, Jusciele Brogin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications.
ROS are generated by exogenous and endogenous factors such as during hyperglycemia.
When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues.
Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations.
These mutations can lead to and/or play a role in cancer development.
This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity.
While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear.
DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood.
Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.
American Psychological Association (APA)
Moreli, Jusciele Brogin& Santos, Janine Hertzog& Rocha, Clarissa Ribeiro& Damasceno, Débora Cristina& Morceli, Glilciane& Rudge, Marilza Vieira Cunha…[et al.]. 2014. DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489697
Modern Language Association (MLA)
Moreli, Jusciele Brogin…[et al.]. DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-489697
American Medical Association (AMA)
Moreli, Jusciele Brogin& Santos, Janine Hertzog& Rocha, Clarissa Ribeiro& Damasceno, Débora Cristina& Morceli, Glilciane& Rudge, Marilza Vieira Cunha…[et al.]. DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-489697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489697