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DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification
Joint Authors
Petralia, Giuseppe
Méndez, C. Andrés
Pizzorni Ferrarese, Francesca
Summers, Paul
Menegaz, Gloria
Source
International Journal of Biomedical Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In order to better predict and follow treatment responses in cancer patients, there is growing interest in noninvasively characterizing tumor heterogeneity based on MR images possessing different contrast and quantitative information.
This requires mechanisms for integrating such data and reducing the data dimensionality to levels amenable to interpretation by human readers.
Here we propose a two-step pipeline for integrating diffusion and perfusion MRI that we demonstrate in the quantification of breast lesion heterogeneity.
First, the images acquired with the two modalities are aligned using an intermodal registration.
Dissimilarity-based clustering is then performed exploiting the information coming from both modalities.
To this end an ad hoc distance metric is developed and tested for tuning the weighting for the two modalities.
The distributions of the diffusion parameter values in subregions identified by the algorithm are extracted and compared through nonparametric testing for posterior evaluation of the tissue heterogeneity.
Results show that the joint exploitation of the information brought by DCE and DWI leads to consistent results accounting for both perfusion and microstructural information yielding a greater refinement of the segmentation than the separate processing of the two modalities, consistent with that drawn manually by a radiologist with access to the same data.
American Psychological Association (APA)
Méndez, C. Andrés& Pizzorni Ferrarese, Francesca& Summers, Paul& Petralia, Giuseppe& Menegaz, Gloria. 2012. DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification. International Journal of Biomedical Imaging،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489701
Modern Language Association (MLA)
Méndez, C. Andrés…[et al.]. DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification. International Journal of Biomedical Imaging No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-489701
American Medical Association (AMA)
Méndez, C. Andrés& Pizzorni Ferrarese, Francesca& Summers, Paul& Petralia, Giuseppe& Menegaz, Gloria. DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification. International Journal of Biomedical Imaging. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489701