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The Effect of Preoperative Melatonin on Nuclear Erythroid 2-Related Factor 2 Activation in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Joint Authors
Mirmohammad-Sadeghi, Mohsen
Javanmard, Shaghayegh Haghjooy
Ziaei, Amin
Ziaei, Ehsan
Ziaei, Saeid
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
During and after coronary artery bypass grafting (CABG), oxidative stress occurs.
Finding an effective way to improveantioxidant response is important in CABG surgery.
It has been shown that patients with coronary heart disease have a low Melatonin production rate.
The present study aimed to investigate the effects ofMelatoninon nuclear erythroid 2-related factor 2(Nrf2) activity in patients undergoing CABG surgery.
Thirty volunteers undergoing CABG were randomized to receive 10 mg oral Melatonin (Melatonin group, n=15) or placebo (placebo group, n=15) before sleeping for 1 month before surgery.
The activatedNrf2 was measured twice by DNA-based ELISA method in the nuclear extract of peripheral blood mononuclear cells of patients before aortic clumps and 45 minutes after CABG operation.
Melatonin administration was associated with a significantincrease in both plasma levels of Melatonin and Nrf2 concentration in Melatonin group compared to placebo group, respectively (15.2±4.6 pmol/L, 0.28±0.01 versus 1.1±0.59 pmol/L, 0.20±0.07, P<0.05).
The findings of the present study provide preliminary data suggesting that Melatoninmay play a significant role in the potentiation of the antioxidant defense and attenuate cellular damages resulting from CABG surgery via theNrf2 pathway.
American Psychological Association (APA)
Javanmard, Shaghayegh Haghjooy& Ziaei, Amin& Ziaei, Saeid& Ziaei, Ehsan& Mirmohammad-Sadeghi, Mohsen. 2013. The Effect of Preoperative Melatonin on Nuclear Erythroid 2-Related Factor 2 Activation in Patients Undergoing Coronary Artery Bypass Grafting Surgery. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-489704
Modern Language Association (MLA)
Javanmard, Shaghayegh Haghjooy…[et al.]. The Effect of Preoperative Melatonin on Nuclear Erythroid 2-Related Factor 2 Activation in Patients Undergoing Coronary Artery Bypass Grafting Surgery. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-489704
American Medical Association (AMA)
Javanmard, Shaghayegh Haghjooy& Ziaei, Amin& Ziaei, Saeid& Ziaei, Ehsan& Mirmohammad-Sadeghi, Mohsen. The Effect of Preoperative Melatonin on Nuclear Erythroid 2-Related Factor 2 Activation in Patients Undergoing Coronary Artery Bypass Grafting Surgery. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-489704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489704