Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia
Joint Authors
Sasaki, Motoko
Nakanuma, Yasuni
Harada, Kenichi
Sato, Yasunori
Source
International Journal of Hepatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Biliary intraepithelial neoplasia (BilIN) is a precursor lesion of hilar/perihilar and extrahepatic cholangiocarcinoma.
BilIN represents the process of multistep cholangiocarcinogenesis and is the biliary counterpart of pancreatic intraepithelial neoplasia (PanIN).
This study was performed to clarify the histological characteristics of BilIN in relation to PanIN.
Using paraffin-embedded tissue sections of surgically resected specimens of cholangiocarcinoma associated with BilIN and pancreatic ductal adenocarcinoma associated with PanIN, immunohistochemical staining was performed using primary antibodies against MUC1, MUC2, MUC5AC, cyclin D1, p21, p53, and S100P.
For mucin staining, Alcian blue pH 2.5 was used.
Most of the molecules examined here showed similar expression patterns in BilIN and PanIN, in which their expression tended to increase along with the increase in atypia of the epithelial lesions.
Significant differences were observed in the increase in mucin production and the expression of S100P in PanIN-1 and the expression of p53 in PanIN-3, when compared with those in BilIN of a corresponding grade.
These results suggest that cholangiocarcinoma and pancreatic ductal adenocarcinoma share, at least in part, a common carcinogenic process and further confirm that BilIN can be regarded as the biliary counterpart of PanIN.
American Psychological Association (APA)
Sato, Yasunori& Harada, Kenichi& Sasaki, Motoko& Nakanuma, Yasuni. 2014. Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-489752
Modern Language Association (MLA)
Sato, Yasunori…[et al.]. Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia. International Journal of Hepatology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-489752
American Medical Association (AMA)
Sato, Yasunori& Harada, Kenichi& Sasaki, Motoko& Nakanuma, Yasuni. Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-489752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489752