Building and Repairing the Heart : What Can We Learn from Embryonic Development?
Joint Authors
Resende, Tatiana P.
Pinto-do-Ó, Perpétua
Freire, Ana G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mammalian heart formation is a complex morphogenetic event that depends on the correct temporal and spatial contribution of distinct cell sources.
During cardiac formation, cellular specification, differentiation, and rearrangement are tightly regulated by an intricate signaling network.
Over the last years, many aspects of this network have been uncovered not only due to advances in cardiac development comprehension but also due to the use of embryonic stem cells (ESCs) in vitro model system.
Additionally, several of these pathways have been shown to be functional or reactivated in the setting of cardiac disease.
Knowledge withdrawn from studying heart development, ESCs differentiation, and cardiac pathophysiology may be helpful to envisage new strategies for improved cardiac repair/regeneration.
In this review, we provide a comparative synopsis of the major signaling pathways required for cardiac lineage commitment in the embryo and murine ESCs.
The involvement and possible reactivation of these pathways following heart injury and their role in tissue recovery will also be discussed.
American Psychological Association (APA)
Freire, Ana G.& Resende, Tatiana P.& Pinto-do-Ó, Perpétua. 2014. Building and Repairing the Heart : What Can We Learn from Embryonic Development?. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489840
Modern Language Association (MLA)
Freire, Ana G.…[et al.]. Building and Repairing the Heart : What Can We Learn from Embryonic Development?. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-489840
American Medical Association (AMA)
Freire, Ana G.& Resende, Tatiana P.& Pinto-do-Ó, Perpétua. Building and Repairing the Heart : What Can We Learn from Embryonic Development?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-489840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489840