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Advances in Cell Transplantation Therapy for Diseased Myocardium
Joint Authors
Harjula, Ari
Pätilä, Tommi
Villet, Outi M.
Kankuri, Esko
Vento, Antti
Siltanen, Antti
Mahar, M. Ali A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The overall objective of cell transplantation is to repopulate postinfarction scar with contractile cells, thus improving systolic function, and to prevent or to regress the remodeling process.
Direct implantation of isolated myoblasts, cardiomyocytes, and bone-marrow-derived cells has shown prospect for improved cardiac performance in several animal models and patients suffering from heart failure.
However, direct implantation of cultured cells can lead to major cell loss by leakage and cell death, inappropriate integration and proliferation, and cardiac arrhythmia.
To resolve these problems an approach using 3-dimensional tissue-engineered cell constructs has been investigated.
Cell engineering technology has enabled scaffold-free sheet development including generation of communication between cell graft and host tissue, creation of organized microvascular network, and relatively long-term survival after in vivo transplantation.
American Psychological Association (APA)
Villet, Outi M.& Siltanen, Antti& Pätilä, Tommi& Mahar, M. Ali A.& Vento, Antti& Kankuri, Esko…[et al.]. 2011. Advances in Cell Transplantation Therapy for Diseased Myocardium. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489841
Modern Language Association (MLA)
Villet, Outi M.…[et al.]. Advances in Cell Transplantation Therapy for Diseased Myocardium. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-489841
American Medical Association (AMA)
Villet, Outi M.& Siltanen, Antti& Pätilä, Tommi& Mahar, M. Ali A.& Vento, Antti& Kankuri, Esko…[et al.]. Advances in Cell Transplantation Therapy for Diseased Myocardium. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489841