The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections
Joint Authors
Tennert, Karin
Boscheinen, Jan Bernardin
Schmidt, Barbara
Schuster, Philipp
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In 1999, two independent groups identified plasmacytoid dendritic cells (PDC) as major type I interferon- (IFN-) producing cells in the blood.
Since then, evidence is accumulating that PDC are a multifunctional cell population effectively coordinating innate and adaptive immune responses.
This paper focuses on the role of different immune cells and their interactions in the surveillance of alpha herpes virus infections, summarizes current knowledge on PDC surface receptors and their role in direct cell-cell contacts, and develops a risk factor model for the clinical implications of herpes simplex and varicella zoster virus reactivation.
Data from studies involving knockout mice and cell-depletion experiments as well as human studies converge into a “spider web”, in which the direct and indirect crosstalk between many cell populations tightly controls acute, latent, and recurrent alpha herpes virus infections.
Notably, cells involved in innate immune regulations appear to shape adaptive immune responses more extensively than previously thought.
American Psychological Association (APA)
Schuster, Philipp& Boscheinen, Jan Bernardin& Tennert, Karin& Schmidt, Barbara. 2011. The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections. Advances in Virology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-489857
Modern Language Association (MLA)
Schuster, Philipp…[et al.]. The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections. Advances in Virology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-489857
American Medical Association (AMA)
Schuster, Philipp& Boscheinen, Jan Bernardin& Tennert, Karin& Schmidt, Barbara. The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-489857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489857