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SELDI-TOF-MS Serum Profiling Reveals Predictors of Cardiac MRI Changes in Marathon Runners
Joint Authors
McCullough, Peter A.
Pruetz, Barbara L.
Geddes, Timothy J.
Thibodeau, Bryan J.
Wilson, George D.
Trivax, Justin E.
Murawka, Amy
Colar, James M.
Source
International Journal of Proteomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Purpose.
To utilize proteomics to discover proteins associated with significant cardiac magnetic resonance imaging (MRI) changes in marathon runners.
Methods.
Serum from 25 runners was analyzed by surface enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS).
Proteomic profiles were compared in serum samples obtained prior to the race, at the finish line and within 7 hours after race to identify dynamic proteins correlated with cardiac MRI changes.
Results.
693 protein/peptide clusters were identified using two ProteinChip surface chemistries and, of these, 116 were significantly different between the three time points.
We identified 7 different patterns of protein expression change within the runners and 5 prerace protein peaks, 16 finish-line protein levels, and 15 postrace proteins which were correlated with significant postrace cardiac MRI changes.
Conclusions.
This study has identified baseline levels of proteins which may be predictive of risk of significant cardiac damage following a marathon race.
Preliminary identification of the significant proteins suggested the involvement of cytokines and other proteins involved in stress and inflammatory response.
American Psychological Association (APA)
Wilson, George D.& Geddes, Timothy J.& Pruetz, Barbara L.& Thibodeau, Bryan J.& Murawka, Amy& Colar, James M.…[et al.]. 2012. SELDI-TOF-MS Serum Profiling Reveals Predictors of Cardiac MRI Changes in Marathon Runners. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489861
Modern Language Association (MLA)
Wilson, George D.…[et al.]. SELDI-TOF-MS Serum Profiling Reveals Predictors of Cardiac MRI Changes in Marathon Runners. International Journal of Proteomics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-489861
American Medical Association (AMA)
Wilson, George D.& Geddes, Timothy J.& Pruetz, Barbara L.& Thibodeau, Bryan J.& Murawka, Amy& Colar, James M.…[et al.]. SELDI-TOF-MS Serum Profiling Reveals Predictors of Cardiac MRI Changes in Marathon Runners. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-489861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489861