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On the Stability of Lung Parenchymal Lesions with Applications to Early Pneumothorax Diagnosis
Joint Authors
Seshaiyer, Padmanabhan
Banerjee, Rohan
Bhandarkar, Archis R.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Spontaneous pneumothorax, a prevalent medical challenge in most trauma cases, is a form of sudden lung collapse closely associated with risk factors such as lung cancer and emphysema.
Our work seeks to explore and quantify the currently unknown pathological factors underlying lesion rupture in pneumothorax through biomechanical modeling.
We hypothesized that lesion instability is closely associated with elastodynamic strain of the pleural membrane from pulsatile air flow and collagen-elastin dynamics.
Based on the principles of continuum mechanics and fluid-structure interaction, our proposed model coupled isotropic tissue deformation with pressure from pulsatile air motion and the pleural fluid.
Next, we derived mathematical instability criteria for our ordinary differential equation system and then translated these mathematical instabilities to physically relevant structural instabilities via the incorporation of a finite energy limiter.
The introduction of novel biomechanical descriptions for collagen-elastin dynamics allowed us to demonstrate that changes in the protein structure can lead to a transition from stable to unstable domains in the material parameter space for a general lesion.
This result allowed us to create a novel streamlined algorithm for detecting material instabilities in transient lung CT scan data via analyzing deformations in a local tissue boundary.
American Psychological Association (APA)
Bhandarkar, Archis R.& Banerjee, Rohan& Seshaiyer, Padmanabhan. 2013. On the Stability of Lung Parenchymal Lesions with Applications to Early Pneumothorax Diagnosis. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-489862
Modern Language Association (MLA)
Bhandarkar, Archis R.…[et al.]. On the Stability of Lung Parenchymal Lesions with Applications to Early Pneumothorax Diagnosis. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-489862
American Medical Association (AMA)
Bhandarkar, Archis R.& Banerjee, Rohan& Seshaiyer, Padmanabhan. On the Stability of Lung Parenchymal Lesions with Applications to Early Pneumothorax Diagnosis. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-489862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489862