Epigenetic Regulation of Apoptosis and Cell Cycle in Osteosarcoma
Joint Authors
Kleinerman, Eugenie S.
Rao-Bindal, Krithi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The role of genetic mutations in the development of osteosarcoma, such as alterations in p53 and Rb, is well understood.
However, the significance of epigenetic mechanisms in the progression of osteosarcoma remains unclear and is increasingly being investigated.
Recent evidence suggests that epigenetic alterations such as methylation and histone modifications of genes involved in cell cycle regulation and apoptosis may contribute to the pathogenesis of this tumor.
Importantly, understanding the molecular mechanisms of regulation of these pathways may give insight into novel therapeutic strategies for patients with osteosarcoma.
This paper serves to summarize the described epigenetic mechanisms in the tumorigenesis of osteosarcoma, specifically those pertaining to apoptosis and cell cycle regulation.
American Psychological Association (APA)
Rao-Bindal, Krithi& Kleinerman, Eugenie S.. 2010. Epigenetic Regulation of Apoptosis and Cell Cycle in Osteosarcoma. Sarcoma،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-489878
Modern Language Association (MLA)
Rao-Bindal, Krithi& Kleinerman, Eugenie S.. Epigenetic Regulation of Apoptosis and Cell Cycle in Osteosarcoma. Sarcoma No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-489878
American Medical Association (AMA)
Rao-Bindal, Krithi& Kleinerman, Eugenie S.. Epigenetic Regulation of Apoptosis and Cell Cycle in Osteosarcoma. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-489878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489878