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Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET
Joint Authors
Miles, K. A.
Griffiths, M. R.
Yu, D.
Williams, R. E.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To assess whether the differences in vascular-metabolic relationships between lymphoma masses and colorectal liver metastases predicted from previous histopathological studies can be demonstrated by dynamic contrast-enhanced CT (DCE-CT) combined with fluorodeoxyglucose positron emission tomography (FDG-PET).
Methods.
DCE-CT and FDG-PET studies were drawn from an imaging archive for patients with either lymphoma masses (n=11) or hepatic metastases from colorectal cancer (CRM: n=12).
Tumour vascularity was assessed using DCE-CT measurements of perfusion.
Tumour glucose metabolism was expressed as the mean FDG Standardised Uptake Value (SUVFDG).
The relationship between metabolism and vascularity in each group was assessed from SUVFDG /perfusion ratios and Pearson correlation coefficients.
Results.
An SUVFDG threshold of 3.0 was used to designate lymphoma masses as active (AL, n=6) or inactive lymphoma (IL, n=5).
Tumour perfusion was significantly higher in AL (0.65 mL/min/mL) than CRM (0.37 mL/min/mL: P=.031) despite similar SUVFDG (5.05 and 5.33, resp.).
AL demonstrated higher perfusion values than IL (0.24 mL/min/mL: P=.006).
SUVFDG/perfusion was significantly higher in CRM (15.3 min) than IL (4.2 min, P<.01).
There was no correlation between SUVFDG and perfusion for any patient group.
American Psychological Association (APA)
Miles, K. A.& Williams, R. E.& Yu, D.& Griffiths, M. R.. 2011. Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489883
Modern Language Association (MLA)
Miles, K. A.…[et al.]. Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET. International Journal of Molecular Imaging No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-489883
American Medical Association (AMA)
Miles, K. A.& Williams, R. E.& Yu, D.& Griffiths, M. R.. Demonstrating Intertumoural Differences in Vascular-Metabolic Phenotype with Dynamic Contrast-Enhanced CT-PET. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-489883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489883