Genome-Wide Analysis of mir-548 Gene Family Reveals Evolutionary and Functional Implications
Joint Authors
Liang, Tingming
Guo, Li
Liu, Chang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
mir-548 is a larger, poorly conserved primate-specific miRNA gene family.
69 human mir-548 genes located in almost all human chromosomes whose widespread distribution pattern implicates the evolutionary origin from transposable elements.
Higher level of nucleotide divergence was detected between these human miRNA genes, which mainly derived from divergence of multicopy pre-miRNAs and homologous miRNA genes.
Products of mir-548, miR-548-5p, and miR-548-3p showed inconsistent evolutionary patterns, which partly contributed to larger genetic distances between pre-miRNAs.
“Seed shifting” events could be detected among miR-548 sequences due to various 5′ ends.
The events led to shift of seed sequences and target mRNAs, even generated to new target mRNAs.
Additionally, the phenomenon of miRNA:miRNA interaction in the miRNA gene family was found.
The potential interaction between miRNAs may be contributed to dynamic miRNA expression profiles by complementarily binding events to form miRNA:miRNA duplex with 5′-/3′-overhangs.
The miRNA gene family had important roles in multiple biological processes, including signaling pathways and some cancers.
The potential abundant roles and functional implication further led to the larger and poorly conserved gene family with genetic variation based on transposable elements.
The evolutionary pattern of the primate-specific gene family might contribute to dynamic expression profiles and regulatory network.
American Psychological Association (APA)
Liang, Tingming& Guo, Li& Liu, Chang. 2012. Genome-Wide Analysis of mir-548 Gene Family Reveals Evolutionary and Functional Implications. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489891
Modern Language Association (MLA)
Liang, Tingming…[et al.]. Genome-Wide Analysis of mir-548 Gene Family Reveals Evolutionary and Functional Implications. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-489891
American Medical Association (AMA)
Liang, Tingming& Guo, Li& Liu, Chang. Genome-Wide Analysis of mir-548 Gene Family Reveals Evolutionary and Functional Implications. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-489891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489891