Nephrogenic Systemic Fibrosis Risk and Liver Disease
Joint Authors
Escudero, Mark R.
Finkelstone, Lee A.
Chow, Daniel S.
Hanna, Robert F.
Miloushev, Vesselin Z.
Lagana, Stephen M.
Prince, Martin R.
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Evaluate the incidence of nephrogenic systemic fibrosis (NSF) in patients with liver disease in the peritransplant period.
Materials and Methods.
This IRB approved study retrospectively reviewed patients requiring transplantation for cirrhosis, hepatocellular carcinoma (HCC), or both from 2003 to 2013.
Records were reviewed identifying those having gadolinium enhanced MRI within 1 year of posttransplantation to document degree of liver disease, renal disease, and evidence for NSF.
Results.
Gadolinium-enhanced MRI was performed on 312 of 837 patients, including 23 with severe renal failure (GFR < 30 mL/min/1.73 cm2) and 289 with GFR > 30.
Two of 23 patients with renal failure developed NSF compared to zero NSF cases in 289 patients with GFR > 30 (0/289; P<0.003).
High dose gadodiamide was used in the two NSF cases.
There was no increased incidence of NSF with severe liver disease (1/71) compared to nonsevere liver disease (1/241; P=0.412).
Conclusion.
Renal disease is a risk factor for NSF, but in our small sample our evidence suggests liver disease is not an additional risk factor, especially if a low-risk gadolinium agent is used.
Noting that not all patients received high-risk gadolinium, a larger study focusing on patients receiving high-risk gadolinium is needed to further evaluate NSF risk in liver disease in the peritransplant period.
American Psychological Association (APA)
Hanna, Robert F.& Finkelstone, Lee A.& Chow, Daniel S.& Miloushev, Vesselin Z.& Escudero, Mark R.& Lagana, Stephen M.…[et al.]. 2014. Nephrogenic Systemic Fibrosis Risk and Liver Disease. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-489897
Modern Language Association (MLA)
Hanna, Robert F.…[et al.]. Nephrogenic Systemic Fibrosis Risk and Liver Disease. International Journal of Nephrology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-489897
American Medical Association (AMA)
Hanna, Robert F.& Finkelstone, Lee A.& Chow, Daniel S.& Miloushev, Vesselin Z.& Escudero, Mark R.& Lagana, Stephen M.…[et al.]. Nephrogenic Systemic Fibrosis Risk and Liver Disease. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-489897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489897