Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas
Joint Authors
Parra, Pilar
Raventós, Nuria
Uribarrena A, Rafael
Ortego, Javier
Uribarrena E, Rafael
Fuentes, Javier
Source
Gastroenterology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die.
Method.
In order to determine if tumor microvascular density (MVD) is a prognostic factor in CRC, samples from tumors of 104 Dukes A-B CRC patients were retrospectively studied.
Immunohistochemistry was performed for anti-CD34 antibody to visualize tumor vascularisation.
MVD was expressed as the total number of vessels and as the percentage of microvascular area.
We calculated MVD with a morphometry program and performed descriptive, bivariate, and survival statistics.
Results.
The mean number of vessels was 37.37/200x field, and the mean vascular area was the 3.972%.
30% of the patients with <37 vessels/field, and 21% of the patients with >37 vessels/field, experienced recurrence/death.
The 35% of patients with <4% of vascular area died following recurrence, compared with 14% of patients with ≥4% of vascular area.
These differences in % of vascular area were statistically significant.
Conclusion.
MVD expressed as the total number of vessels had no a statistically significant influence on the evolution of CRC.
However, neoplasias with a greater % of vascular were associated to a better outcome.
American Psychological Association (APA)
Uribarrena A, Rafael& Ortego, Javier& Fuentes, Javier& Raventós, Nuria& Parra, Pilar& Uribarrena E, Rafael. 2009. Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-489921
Modern Language Association (MLA)
Uribarrena A, Rafael…[et al.]. Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas. Gastroenterology Research and Practice No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-489921
American Medical Association (AMA)
Uribarrena A, Rafael& Ortego, Javier& Fuentes, Javier& Raventós, Nuria& Parra, Pilar& Uribarrena E, Rafael. Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-489921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489921