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Precursor B-Cell Acute Lymphoblastic LeukemiaLymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains : A Case Report
Joint Authors
Gasparini, Robert
Hirzel, Alicia C.
Sriganeshan, Vathany
Cotrell, Aaron
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Acute lymphoblastic leukemia is predominantly found in children.
It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage.
The immature cells in B-acute lymphoblastic leukemia/lymphoma can be small or medium sized with scant or moderate cytoplasm and typically express B-cell markers such as CD19, cytoplasmic CD79a, and TdT without surface light chains.
These markers, along with cytogenetic studies, are vital to the diagnosis, classification, and treatment of these neoplasms.
We present an unusual case of a precursor B-cell ALL, in an 82-year-old woman, who presented with pancytopenia and widespread lymphadenopathy.
The cells show L3 morphology (Burkitt-like lymphoma) with coexpression of TdT and surface light chains in addition to an MYC gene translocation and Philadelphia chromosome.
American Psychological Association (APA)
Hirzel, Alicia C.& Cotrell, Aaron& Gasparini, Robert& Sriganeshan, Vathany. 2013. Precursor B-Cell Acute Lymphoblastic LeukemiaLymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains : A Case Report. Case Reports in Pathology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-489929
Modern Language Association (MLA)
Hirzel, Alicia C.…[et al.]. Precursor B-Cell Acute Lymphoblastic LeukemiaLymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains : A Case Report. Case Reports in Pathology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-489929
American Medical Association (AMA)
Hirzel, Alicia C.& Cotrell, Aaron& Gasparini, Robert& Sriganeshan, Vathany. Precursor B-Cell Acute Lymphoblastic LeukemiaLymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains : A Case Report. Case Reports in Pathology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-489929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489929