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Paliperidone ER in the Treatment of Borderline Personality Disorder : A Pilot Study of Efficacy and Tolerability
Joint Authors
Bogetto, Filippo
Bellino, Silvio
Rinaldi, Camilla
Bozzatello, Paola
Source
Depression Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Antipsychotics are recommended for the treatment of impulsive dyscontrol and cognitive perceptual symptoms of borderline personality disorder (BPD).
Three reports supported the efficacy of oral risperidone on BPD psychopathology.
Paliperidone ER is the metabolite of risperidone with a similar mechanism of action, and its osmotic release reduces plasmatic fluctuations and antidopaminergic effects.
The aim of this study is to evaluate efficacy and safety of paliperidone ER in BPD patients.
18 outpatients with a DSM-IV-TR diagnosis of BPD were treated for 12 weeks with paliperidone ER (3–6 mg/day).
They were assessed at baseline, week 4, and week 12, using the CGI-Severity item, the BPRS, the HDRS, the HARS, the SOFAS, the BPD Severity Index (BPDSI), and the Barratt Impulsiveness Scale (BIS-11).
Adverse events were evaluated with the DOTES.
Paliperidone ER was shown to be effective and well tolerated in reducing severity of global symptomatology and specific BPD symptoms, such as impulsive dyscontrol, anger, and cognitive-perceptual disturbances.
Results need to be replicated in controlled trials.
American Psychological Association (APA)
Bellino, Silvio& Bozzatello, Paola& Rinaldi, Camilla& Bogetto, Filippo. 2011. Paliperidone ER in the Treatment of Borderline Personality Disorder : A Pilot Study of Efficacy and Tolerability. Depression Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-489939
Modern Language Association (MLA)
Bellino, Silvio…[et al.]. Paliperidone ER in the Treatment of Borderline Personality Disorder : A Pilot Study of Efficacy and Tolerability. Depression Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-489939
American Medical Association (AMA)
Bellino, Silvio& Bozzatello, Paola& Rinaldi, Camilla& Bogetto, Filippo. Paliperidone ER in the Treatment of Borderline Personality Disorder : A Pilot Study of Efficacy and Tolerability. Depression Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-489939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489939