Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity
Joint Authors
Santos, Júlia
Sousa, Maria João
Leão, Cecília
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity.
Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS).
Other components of the culture media and factors such as the products of fermentation have also been implicated in the regulation of CLS.
Acidification of the culture media mainly due to acetic acid and other organic acids production negatively impacts CLS.
Ethanol is another fermentative metabolite capable of inducing CLS reduction in aged cells by yet unknown mechanisms.
Recently, ammonium was reported to induce cell death associated with shortening of CLS.
This effect is correlated to the concentration of NH4+ added to the culture medium and is particularly evident in cells starved for auxotrophy-complementing amino acids.
Studies on the nutrient-signaling pathways regulating yeast aging had a significant impact on aging-related research, providing key insights into mechanisms that modulate aging and establishing the yeast as a powerful system to extend knowledge on longevity regulation in multicellular organisms.
American Psychological Association (APA)
Santos, Júlia& Leão, Cecília& Sousa, Maria João. 2012. Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-489951
Modern Language Association (MLA)
Santos, Júlia…[et al.]. Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-489951
American Medical Association (AMA)
Santos, Júlia& Leão, Cecília& Sousa, Maria João. Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-489951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489951