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Accelerated Aging during Chronic Oxidative Stress : A Role for PARP-1
Joint Authors
Timmermans, Leen
Boesten, Daniëlle M. P. H. J.
de Vos-Houben, Joyce M. J.
Hageman, Geja J.
Bast, Aalt
den Hartog, Gertjan J. M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress plays a major role in the pathophysiology of chronic inflammatory disease and it has also been linked to accelerated telomere shortening.
Telomeres are specialized structures at the ends of linear chromosomes that protect these ends from degradation and fusion.
Telomeres shorten with each cell division eventually leading to cellular senescence.
Research has shown that poly(ADP-ribose) polymerase-1 (PARP-1) and subtelomeric methylation play a role in telomere stability.
We hypothesized that PARP-1 plays a role in accelerated aging in chronic inflammatory diseases due to its role as coactivator of NF-κb and AP-1.
Therefore we evaluated the effect of chronic PARP-1 inhibition (by fisetin and minocycline) in human fibroblasts (HF) cultured under normal conditions and under conditions of chronic oxidative stress, induced by tert-butyl hydroperoxide (t-BHP).
Results showed that PARP-1 inhibition under normal culturing conditions accelerated the rate of telomere shortening.
However, under conditions of chronic oxidative stress, PARP-1 inhibition did not show accelerated telomere shortening.
We also observed a strong correlation between telomere length and subtelomeric methylation status of HF cells.
We conclude that chronic PARP-1 inhibition appears to be beneficial in conditions of chronic oxidative stress but may be detrimental under relatively normal conditions.
American Psychological Association (APA)
Boesten, Daniëlle M. P. H. J.& de Vos-Houben, Joyce M. J.& Timmermans, Leen& den Hartog, Gertjan J. M.& Bast, Aalt& Hageman, Geja J.. 2013. Accelerated Aging during Chronic Oxidative Stress : A Role for PARP-1. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-489965
Modern Language Association (MLA)
Boesten, Daniëlle M. P. H. J.…[et al.]. Accelerated Aging during Chronic Oxidative Stress : A Role for PARP-1. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-489965
American Medical Association (AMA)
Boesten, Daniëlle M. P. H. J.& de Vos-Houben, Joyce M. J.& Timmermans, Leen& den Hartog, Gertjan J. M.& Bast, Aalt& Hageman, Geja J.. Accelerated Aging during Chronic Oxidative Stress : A Role for PARP-1. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-489965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489965