Comparative Analysis of Barophily-Related Amino Acid Content in Protein Domains of Pyrococcus abyssi and Pyrococcus furiosus
Joint Authors
Yafremava, Liudmila S.
Di Giulio, Massimo
Caetano-Anollés, Gustavo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Amino acid substitution patterns between the nonbarophilic Pyrococcus furiosus and its barophilic relative P.
abyssi confirm that hydrostatic pressure asymmetry indices reflect the extent to which amino acids are preferred by barophilic archaeal organisms.
Substitution patterns in entire protein sequences, shared protein domains defined at fold superfamily level, domains in homologous sequence pairs, and domains of very ancient and very recent origin now provide further clues about the environment that led to the genetic code and diversified life.
The pyrococcal proteomes are very similar and share a very early ancestor.
Relative amino acid abundance analyses showed that biases in the use of amino acids are due to their shared fold superfamilies.
Within these repertoires, only two of the five amino acids that are preferentially barophilic, aspartic acid and arginine, displayed this preference significantly and consistently across structure and in domains appearing in the ancestor.
The more primordial asparagine, lysine and threonine displayed a consistent preference for nonbarophily across structure and in the ancestor.
Since barophilic preferences are already evident in ancient domains that are at least ~3 billion year old, we conclude that barophily is a very ancient trait that unfolded concurrently with genetic idiosyncrasies in convergence towards a universal code.
American Psychological Association (APA)
Yafremava, Liudmila S.& Di Giulio, Massimo& Caetano-Anollés, Gustavo. 2013. Comparative Analysis of Barophily-Related Amino Acid Content in Protein Domains of Pyrococcus abyssi and Pyrococcus furiosus. Archaea،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489970
Modern Language Association (MLA)
Yafremava, Liudmila S.…[et al.]. Comparative Analysis of Barophily-Related Amino Acid Content in Protein Domains of Pyrococcus abyssi and Pyrococcus furiosus. Archaea No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489970
American Medical Association (AMA)
Yafremava, Liudmila S.& Di Giulio, Massimo& Caetano-Anollés, Gustavo. Comparative Analysis of Barophily-Related Amino Acid Content in Protein Domains of Pyrococcus abyssi and Pyrococcus furiosus. Archaea. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489970